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The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity

doi: 10.1016/j.schres.2020.05.044 195 ClarkSMNotarangeloFMLiXChenSSchwarczRTonelliLH

Millifluidic culture improves human midbrain organoid vitality and differentiation

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This complex interaction regulates hepatic metabolism and modulates brain function, thereby playing a pivotal role in maintaining systemic metabolic homeostasis and contributing to the pathophysiology of various diseases (Figure.1)